Your best bet is to get one or two 150GB Raptors and an auxillary 500GB drive to store your media (music,pictures, doccuments, movies, etc) on.
Here is how I have it set up:
Two 150GB Raptors: One holds the operating system and related stuff. The second Raptor has all my installed programs on it. This method is better than RAID 0 and it offers better mulititasking ablilites and program load times. Do not install any non-os related (updates, patches,etc) on to the OS drive (C:\). Install all programs on to the (D:\) second Raptor. Mixing programs with the OS drive can hamper performance.
The Thrid Drive is one large 500GB for all my songs, pictures, bit-torrent, downloads, drivers, etc.
I also have a 320GB 1394 Mybook that I use to as a back up my pictures, music, Chipset drivers, and NIC drivers. No other drivers need to be saved or backed up, they can be re-downloaded once the chipset and nic have been installed.
-Megaohm
CompTIA Member