If your Klipsch Promedia 2.1/4.1 speaker system is making static/crackle noise or just can not power up, below are some possible solutions.
Note that these solutions are just from links that I've gathered over a few hours so don't get your hope up.
If you have the money and don't have the time: see quick fix 6.
If the speaker can not power up: see fix 2,3,5.
If there's no sound from one of the speakers: see fix 2, 3, 5.
If there's static/crackle noise when turning the volume knob: see fix 4.
If the speaker is making random static/crackle noise: see fix 1,2,3,4 (in this order).
Fix 1. If you have turned off your speaker for several days, try "warming it up" by powering up the speaker for few hours (with the speaker off or mute the volume) ( 1)
Fix 2. Isolate the speaker by moving the speaker from all other electronics, wires. Switch to a different power source/plug, unplug and replug all wires. This will identify if the problem is due to interference of other electronics or due to the speaker itself ( 2).
Fix 3. Check for broken electronic components in the control pod and the amplifier inside the sub woofer ( 3,4) visually, then with a voltmeter and the schematic of your speaker system ( 5).
Fix 4. Clean the knob with contact cleaner ( 6).
Fix 5. Check if the DIN is broken, if yes replace the DIN yourself ( 7,8) or find someone that'll do it for you ( 8).
Fix 6. Buy a speaker with better quality and fewer design flaws.
Reference
( 1) My own experience. Powering on the speakers for half a day actually solved my speaker's static/crackle problem, I went from Fix 2, to 4,3,4,3,4,3 then finally tried Fix 1, which finally solved my speaker's problem (and I have no idea why fix 1 resolved my speaker's random static noise problem).
( 2) http://www.hometheaterforum.com/t/303683/all-my-surround-sound-speakers-have-static-crackle
( 3) http://hardforum.com/showthread.php?t=1333618
( 4) http://community.klipsch.com/forums/t/152429.aspx
( 5) http://www.thompdale.com/bash_amplifier/bash_amp.htm
( 6) http://community.klipsch.com/forums/p/124202/1255366.aspx
( 7) http://community.klipsch.com/forums/t/111840.aspx
( 8) http://community.klipsch.com/forums/p/132709/1346623.aspx