After many subwoofers get older, sometimes it is simply the amplifier that goes. I have an older KSW-100 that recently went a couple of months ago. I called Klipsch, ordered a replacement amp unit (cost was approx. $170), and did the replacement. The unit works fantastic again.
Another reason fuses can blow is that you may have an electrical "short" in which the two leads may be touching each other.
Another reason is that the amp rating of the replacement fuses you are using is too low. However, you also have to be careful about choosing a fuse with too high an amp rating which might never blow thereby instead causing your amplifier to blow out.