I'm on my 3rd aftermarket head unit in the car, all three have the front-panel USB input. I think they max out at recognizing16Gb.
I repurposed #'s1 and 2 USB-capable car units. Now, each is packaged with a class D switching power supply, ~ 13.8V DC output, maybe 2500 mA, and serve as lines-powered dedicated/portable MP3 music servers.
One's in a metal 'CB Radio' enclosure, and the other's in a soft-side bag W strap. As for the thumb drives, I've put different genres on different ones ....Holiday tunes, Party, etc.
Leo