Bosco-d-gama
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Posts posted by Bosco-d-gama
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11 minutes ago, dwilawyer said:
You do need some physicians and nurses on site, not to administer, but on standby, that's a requirement, at least in Texas.
Y’know they can cut through the red tape if they wanna. Anaphylaxis occurs at 2 cases per million. Keep an ambulance on stand by like most HS football games.
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7 minutes ago, dwilawyer said:
But you have to pay them to show up at a hub, or, order them to show up if in Military or Guard.
I think we need to get a realistic grasp on the scale we are looking at here.
Let's assume no supply problem, there are dose for everyone who can take it (above age what?). Does anyone know that number? 250 Million?
So you stagger that out by priority, done.
Let's take the example of lining everyone up like boot camp. That would be Army, NG is a fraction so new recruits for NG would send you backwards. New Recruits for Army is about 80,000 I believe, or at least their goal. So we know they have that capability, staggegered out over a year, all over US. Let's say they are capable of doing 10x that. 800,000 injections per year. 100x that 8,000,000 a year. That's the US Army, not the Guard which is tiny, in 54 seperate entities.
The Guard and Military are the best for getting large scale supplies of anything, to an area, and distributing those supplies, there is no question about that. But it only one piece of the puzzle. You need to have people to administer it.
That all assumes no supply issues.
It there was an unlimited supply there wouldn't be any issues would there? You ask every pharmacy, doctor, hospital, health department how many they need and send them out X2, 2 shots. Oh that's right, you have to have special freezers . . . until now.
The JJ numbers are now ultra critical. What was effectiveness IN THE US, and on those that got it in US what was outcome compared to control group? Are those numbers acceptable? What is JJ's capacity?
Effective population vaccinations for the influenza are considered anything above a 60% success rate. A population with this level of immunity will impede the spread of the flu enough to quell an outbreak. I believe I have read where they want something similar or better for covid19. The vaccines themselves achieve individual functional levels above 90% which is extraordinary. But to impede new variations we need to get as many vaccinated ASAP and adhere to masking, etc for the balance of this calendar year, if not longer.
Insofar as logistics go..... not my bailiwick. What I would note is that large sized installations are needed to accommodate large crowds. A queue at the local pharmacy isn’t gonna work. Hopefully brighter minds than mine are working on the solutions.
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10 minutes ago, dwilawyer said:
True, you don't want an MD any way. Pharmacists can do it in every state already, nurse assistants, lots of.people qualified, but you have to pay them.
National Guard is State by State, but how many total medics, corpsmen total in National Guard? By state?
The goal is 1million a day,.where are we at currently?
Every retired nurse, medic, doctor, Pharmd and anyone willing to undergo 30 minutes of training can give a safe IM injection. It truly is abc123 easy...... then again so is wearing a mask.
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3 minutes ago, dwilawyer said:
State by state, Hubs. To bump up to 1 million vaccinations a day I don't what's in plan for that. National Guard, CVS?
You have to have supply before you can use National Guard. You would use National Guard at Hubs capable of vaccinating 25K to 50K a day, hard to do that in-car. You have to have the supply first,.then who is going to pay the nurses and doctors to go down the hub?
What's the avg. Number of vaccinations per day now? What's the supply per day at?
How much can.JJ pump out?
You do not need MD’s and/or RN’s to administer simple intramuscular injections. It is the same deal as boot camp. Line em up and medics inject - done.
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This might be a wrong idea...... but I’d like to see the national guard deployed to administer these vaccinations. I think they need a simplified command route to distribute and deploy this stuff. With the guard it goes from source to dispensary to the people. Giving IM injections is simple. Now we’ve got too many outlets, too many routes, too many promises and too many chiefs and things are getting bottlenecked, botched, lost and wasted. Simplify it - use the guard IMHO.
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37 minutes ago, dwilawyer said:
You are indeed a great source. However, I would like to stay away from comparisons between the old efforts and new efforts. It just makes it hard to keep this boat upright. I really need for everyone to stay in the here and now boat (which for the most part has been happening).
This is for everyone, no one in particular just an opportunity to review what this thread is about - apolitical current, credible information on the virus, what's working, what isn't, vaccinations (getting or not getting). It's going to need some science behind it. The kind of stuff people need to make today, real world decisions. Unfortunately (or maybe fortunately) fringe won't make it here, nor commentary, then vs. now, China, etc. You could try a new topic but I doubt it will last, too hot button, but welcome the try.
Final note, I'm not going to control what's credible here. You all have been pretty good at point out what's right cornering with stuff. We need to know.what mainstream "science" knows,.also need to know what it doesn't know yet (probably more important), and what is in controversy.
Again, if there is a conspiarcy that's driving something, or another country, whatever, I'm glad they figured it out, it doesn't belong here. Everyone here is more than capable of staying up to date and looking up whats behind all of this, then or now. (Dick Cheny and Bill Gates are all running this from Montana at Ted's ranch, as entertainment in a game they have dubbed The Unknown, Known in case you were wondering). That information is easy to find, everyone here can find it.
What's difficult to find and sort through is what's is current, accurate and scientific, why something is suspect, if there are different views in scientific community, what therapeutics are working, are not. That's the hard stuff to find, but you all have found it, over and over, since March.
Let me know if any questions. I'm happy to try to clarify. It's a thin line I know, but the only way to keep this topic around (most other forums tossed it long ago). The line has shifted, or been defined very well, my fault, sorry.
It takes, liberally, a 1000 times the effort to keep this on the rails than to lock it and prohibit any related future topics, but, so far, it's been worth the effort.
You have a PM.....👍
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43 minutes ago, billybob said:
Then, we shall see...
I am hopeful. I wish I was more optimistic. Covid19 is a most challenging foe. Where we’ve lost the biggest battles have been with masses. Fingers and toes crossed.
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7 hours ago, tube fanatic said:
Vaccine distribution in NJ. The cartoon reminds me of the amps built by a certain unnamed individual!
Based on the experiences of everyone I know the article is 100% accurate.
Maynard
Edited by Moderator:
Absolutely! The need to 911 vaccinate huge masses of people is an enormous task that was [Edit "was" refers to the past, not what thread is about. Here and now.]
Who is failing? [Not on topic, you could try new thread, but good luck keeping politics out of that.]
Never expect your elected leadership to [that could actually probably be saved, and would be an excellent topic - it would be a discussion on how to handle the next one]
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15 minutes ago, Foxman said:
I have in the ballpark of 11,000-15,000 books with nearly 10,000 of those digital.
Had a friend whose great aunt was an editor in NYC during the 1st half of the 20th century. She’d inherited a garage full of books. The only one of note I can recall was a Hitler signed copy of Mein Kampf. Guess it was more notorious than note worthy.
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27 minutes ago, Marvel said:
So... your collection is a real pane?
Genuinely....... Every window has at least 1 piece hanging (that includes all the bathroom windows) and we have stuff displayed on easels. We have another 25 big pieces stored and about 200 smalls in boxes. We’d planned on the art festivals last year but they got covid19 cancelled. 😔
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We all collect memories. Some choose to gather and curate objects of rarity or interest. Some suffered deprived childhoods and just hoard to ‘have’ to nurture that void. For myself the things I keep around my house need to contribute to the whole and that means a mixture more than a collection. One intriguing antique or a piece of art can anchor a wall or niche. But I do not like clutter so there’s no ‘massing’ of collections for the sake of having every element of any genre.
My stained glass hobby drives an obscure notion that maybe, someday my work will be desired enough to be considered noteworthy, or collectible. For now each piece is just a challenge. But between the Mrs and myself we have a lot of stained glass. So it constitutes a collection. 👍🤪
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Ruh - Roh............. Looks like Cuomo could be in for a code brown, a well deserved code brown.😔
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27 minutes ago, CECAA850 said:
That's a great way to look at it. Most people prefer not to be Guinea pigs and that's exactly how it feels. Uncharted territories with no long term studies make me uneasy as well.
Well it is a stretch. The covid19 vaccines have passed all known testing metrics for safety. Keep in mind that passing is not a perfect score. But the same measures were applied to these vaccines that have been applied to all other vaccines. So in this measure they are essentially the same. What is different is how the covid19 vaccines were derived. This is where the ‘express lane’ was taken that is new. And what’s ‘new’ is not the end goal but the route taken. So to make the Ebola vaccine they knew what they needed and took the traditional long route albeit as fast as they could. We could’ve done the same for covid19 and we’d have the same results in another 12 to 18 months and nowhere near enough vaccine to make much difference at that juncture. Basically they used a man made biological catalyst to speed up the processes to get to the same place they’d have gone otherwise. So it is not as dire as perhaps it sounds and it is working and it is more efficacious than any influenza vaccine ever produced.
I’d suggest that we should swell up with pride at the accomplishment and relish what the effort may bring us in the very near future in the form of other drugs.
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Here’s another Avenue of medical research aimed at treating infectious diseases. Cutting edge microbiology is poised to make great strides...... if we don’t kill ourselves 1st.
https://phys.org/news/2021-01-newly-molecule-disrupts-virus-infections.html
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32 minutes ago, tube fanatic said:
Yes, but did you review the links to the FDA, et al, presented by some commenters? As reported in this article, there is concern in Japan (and other countries) about this phenomenon:
As reported in Japan Times:
‘Dr. Tetsuo Nakayama, a project professor at Kitasato Institute for Life Sciences and director of the Japanese Society of Clinical Virology, says although the vaccines under development by Pfizer and Moderna successfully created antibodies in trials, there are still doubts about whether those antibodies remain a year or two after vaccination.
There are also underlying concerns about the vaccines’ safety over the long term. Judging from past precedents, their safety and effectiveness are not something that can be determined until at least a year after a massive number of vaccinations have been administered, experts say.
In a worst-case scenario, antibodies could worsen the disease by essentially helping the infection of cells — a phenomenon called antibody dependent enhancement (ADE) — rather than fighting the virus pathogens.
For example, a dengue fever vaccine made by Sanofi, based on a yellow fever vaccine embedded with a part of the dengue virus genome, at first appeared to be effective. But it caused the deaths of children who had been given the vaccination due to the ADE phenomenon.
“Concerns over ADE still remain. I am an elderly person myself, but if I were asked, I would say I don’t want to get a shot,” Nakayama said. “Not all of the 120 million people (in Japan) should get the vaccinations. Children, for example, would not need it because there’s scarcely any risk of severe cases.” ‘
I guess where we differ is that I consider information from FDA and CDC as being the least truthful in comparison with what is disclosed by similar agencies in the rest of the world. It seems that the domestic point of view is different more often than in agreement. To each his own.....
Maynard
Where we differ is does the cure kill the patient and for the time being it doesn’t. We have covid19 and already it has mutated and it will continue to do so unless we can hamper its spread and recurrence. With what we have we know that a surge of covid19 can bring huge cities and the best medicine can offer to their knees. It has got to end ASAP before it mutates into something uglier.
So science has new tools and these tools allow us to accelerate the development of medicines used to treat covid19 and other diseases. As always the proof is in the applications. They’ve done the safety testing and we deployed vaccinations safely. So in a sense covid19 has put humanity in the position of being the guinea pig. We will differ on this need. I believe it is working safely and I believe that the experience will usher in new generations of medicines with unheard potential. It is possible that we will be able to vaccinate against types of cancers (other than HPV). We are moving forward and as it often happens humanity does this when survival challenged. Covid19 brought us to this threshold and new we get to cross into uncharted territories sooner than otherwise.-
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33 minutes ago, dwilawyer said:
Didn't read the article, but this was the rage in the 90s, patients who asked doctors for an Rx of antibiotics were all too happy to give the Rx even though it doesn't do anything for flu, colds, etc.
The issue has long been "disclosed", by everybody, but people will still ask for a pill because that's what we do.
ADE is different than antibiotic resistant organisms. It is a more subtle relationship of a virus to its host and the host response to a viral infection. Essentially the concern is that a vaccine may inadvertently supercharge the virus. The underlying concern is how these covid19 vaccines have been developed using manufactured DNA methods. Getting the vaccine was quicker because science could build the genetics needed to derive them. But genetics is powerful juju and has its incumbent concerns.
Personally I look at it this way. On a separate issue we have global warming. It is clearly related to human activity and it is coming quickly, quicker than it has ever occurred naturally. For some the solution is slam on the carbon emission brakes and duck and cover. For others they seek answers in newly applied carbon capture engineering........ and IMHO this is the only workable answer. That’s because it offers the only solutions that can work enough in the short time frames needed and it is independent of worldwide participation in carbon reduction. Covid medicines are in the same time sensitive situation and advanced science offers the best opportunity to contain them fast enough.
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16 minutes ago, tube fanatic said:
Antibody dependent enhancement is a possible concern not only with the virus itself but also with the vaccines. The issue is not being disclosed to the public by the FDA, CDC, and the media. The comments which follow the article raise very interesting questions about this with some links which support the concerns.
https://blogs.sciencemag.org/pipeline/archives/2020/12/18/antibody-dependent-enhancement
Maynard
Paraphrasing from the blog post: As yet there’s no definitive proof that antibody dependent enhancement ADE is occurring with covid19. And similarly there’s no demonstration of ADE being part of any vaccine pathways (again per the author).
So while his concerns are actual they are not factual. What is clear from this post is just how complex virology is and why people need to listen to the advice from the medical community. As far as ADE goes it is among many pathways that make microorganisms pathological or more pathological, if you will. Looking for the ADE pathway in covid19 is being done and as the author noted it has not been found. If he chooses to fret himself into an ulcer over its prospect he may as well take anxiolytics for earthquakes, tsunamis and asteroids. For now he is merely borrowing trouble when the world has plenty of real covid19 troubles in play.
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So - The WHO held a pandemic review conference to study what went wrong with covid19 and their findings are little more than a politically correct solicitation for more funds. For starts they cite lack of preparedness and slow responses with poor communications. They want more $$$ because they feel that they should be the worlds infectious disease watchdog and healthcare facilitator.
Technically they are correct. They merely cited the idyllic organizational circumstances that would (have) done much better.
But in reality The WHO is nowhere near that idyllic organization and this report emphasizes this point. The key things missing are the very ones that caused the pandemic. The country of origin intentionally withheld timely response and still impedes investigation into covid19 origins. The country of origin is an economic giant and yet offers The WHO 0.02% of their existing budget. I use the term ‘country of origin’ because in this report The WHO never once mentions China. That says that The WHO still bows to state politics and will not ever be the idyllic organization needed to manage/circumvent a pandemic. They are gutless and allow themselves to get used/abused. Covid19 is their billboard of failure and to this day China is defining how the WHO works.
But they want more $$$. And guess who will most likely respond and who won’t? They seek to expand their foundations when current events prove these purposes to be unreachable. The WHO needs revamping and absolutely new leadership. The report is a pie-in-the-sky answer. But the real question is why did The WHO fail in their existing mission and they did not examine their own failings....... and today in Wuhan China The WHO continues to fail the world they supposedly serve.
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10 hours ago, BigStewMan said:
@Bosco-d-gama I know what you mean. I have bilateral profound hearing loss. I got my first set of hearing aids in 2012. Music doesn't sound natural; but at least I can hear. People think that hearing aids are magic ... I still don't hear as well as others. without hearing aids, I don't hear until 70db according to the audiologist. The silver lining is that the doctor says if the sound gets to the eardrum my hearing is fine ... so it's a matter of power, delivering the sound. hearing aids can do that.
I bought the first pair out of pocket, then applied for VA benefits, now I get them for free (a new pair every five years on average). I think the first pair was $6,000 back then. Not happy spending that money; but two weeks later, met the actress Rhona Mitra and we were able to have a conversation with me only asking her to repeat herself once. So, I walked away from that encounter saying that I wouldn't complain about the cost of the hearing aids. No way, I could have had that conversation with her before hearing aids. I would have had to resort to my charm and good looks instead of my captivating conversation skills. I have encountered situations (back when I was working) when people would say "turn your hearing aids up." Like I said, I believe they think they're magic ... helpful definitely ... still a struggle to hear yes.
I have hearing aids where the receiver sits up and behind the ear. I am told the microphones are located posterior laterally. In fact functionally they seem to be posterior - pointing backwards. So the sounds they pick up and amplify are from the rear fields. Works okay for just one thing, one on one conversation. More than a few people talking and I pick up more collateral noise than what I am trying to listen to. Music is affected in the same manner. The proverbial ‘sound stage’ is not achievable any longer. Getting elderly sucks big-time. Gotta think that with modern technology that they could do better. This is probably true - but at what cost?
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Exacerbation of hearing loss in the elderly, yet another collateral consequence of the covid19 ‘mess’. For those (myself included) with significant hearing deficits being amongst others with everyone in masks has impacted the sense of hearing. Oddly this article does not mention the one thing I’d imagine would be part of the problem - that masks muffle sounds. Anything that confounds transmission of sounds impairs me greatly. Listening in crowds and I simply cannot distinguish individual voices or participate in conversations. I appear disinterested or worse but in fact I simply cannot hear regardless of hearing aids. Now since the covid19 also keeps me away from crowds that is not an issue for now. But imagine being in a long term care facility where everyone wears masks and most residents suffer from hearing dysfunction. The masks must bury the spoken voice for them.
https://www.foxnews.com/health/coronavirus-face-masks-hearing-loss-survey
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I use Eliptracs but mine are 2 inch. Keeping mine but maybe if you could use the larger driver you might find your horns quicker. I use the older JBL 2482 drivers. Jammin’ Jersey in Southern California should have these drivers and other options. Last I looked there they had a pair of JBL 2480 drivers that are pretty rare. Bruce Edgar said the JBL 2480’s were ideal for Khorn midrange purposes. I could not find any when I was in the building mode.
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......gonna run the exhaust full open?
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9 minutes ago, BigStewMan said:
are you referring to treat & street the patients? I guess an ER would still be overwhelmed; but not the ICU. what would drive such a decision ... the severity of the illness or the sheer number of infected? both can present problems for a hospital.
To be more specific. A treatment would be something simply administered that would mitigate the progression of the disease. You’d get sick but nowhere near as seriously ill as we see now. It is like finding the Achilles heel for the pathogen. We do this with tuberculosis now. We could vaccinate for tuberculosis and it would work. It would cost a lot and (in this instance) it will mask skin testing for the disease. So instead of vaccinating for tuberculosis we diagnose active cases and treat the disease. For now we can cure tuberculosis. If we did the same for covid19 then you have a ‘bingo’ moment.
Is it even worth it? Should I pull the plug?
in Lounge
Posted
Been there, done with that. Perhaps it is mantra but some folks seem to have ‘bad’ tube luck. Anyway I went with high end solid state. I use an Accuphase E530 integrated amp. Never looked back. The unit has required 1 service in 12 years of pretty much daily usage.