In my experience, one uses either a PC or a Mac to configure it. I have never tried to use it to control a PC Media server, but that's not to say that it cannot perform those functions. My hub is connected wirelessly to my network, so it should be able to access it if configured properly. I use JRiver on a PC to rip all of my CD's and then stream them via Sonos to a Marantz 7008, and through a Nuvo system as well. The Marantz has the ability to connect and play from my PC, but Sonos does a much better job of getting my digital media to my system. The Harmony apps for iPhone &iPad seem to work pretty well also. I like that if I get into a situation where I inadvertently let the actual remote battery die, I still have the ability to control my system. I just like the idea of redundant backups. I never had that with my MX series remote. It worked great when I had it, but, the one I had gave little or no warning when the batteries were low, so next thing you know your remote isn't working. Generally one has spare batteries around the house, but more than once I had to chase out of the house to get batteries. Very annoying!! Good luck with your search, both have great features and I am sure the capabilities just continue to improve.
One other note, part of my reasoning for the Harmony, is that my system is not in my main listening area. The harmony, with wifi and rf capabilities solves that issue as well.