I think the 440c and the 450c with 4 woofers do have an advantage over the Centers with 2 woofers.
In the 440c and 450c two woofers are used up to 500Hz and 2 other woofers are used for 500Hz till 1500Hz, which reduces Frequency Modulation distortion compared to the 250c which uses two woofers that handle lowest frequency up to 1800Hz.