$/dB I think it comes out to about the same...but I guess it depends on your goals. Mounting four $300 drivers in the cieling doesn't cost too much beyond the cost of the drivers (so let's call it $1500) - I bet you could easily drop $1500 on a huge bass horn (a sheet of plywood costs like $40-$80 depending on how nice you want it - multiplied by 10 is pusing $600, then add a $300 driver which comes to $900 and then a few hundred for finishing and nails and all that). I think the few hundred dollar difference makes up for itself when you take into account the amount of floor space you save (perhaps we should include the average price per square foot of our houses too)
4 15"s in the ceiling wont acheive the same SPL. Their sensitivity will be about 90dB/1watt vs 105dB/1watt for the one hornloaded driver.. Ofcourse the sealed box response will roll off nicely to give about 80dB/1watt at 20hz.
I wouldnt use ply,its not going to move.
For the LF I wouldnt consider basshorns,they approach ROOM size.. For the midbass,yes. Most of use dont need it that loud anyway.
Apples vs oranges. Would be cool to integrate it with the design of a new house though!