Different speaker wire can make a difference, however, the threshold of diminishing returns is where people tend to find the most varied opinions. Personally, I've landed on exterior low voltage cable from Home Depot. Comes in 14GA and 12GA, has a nice thick black jacket, and lays flat almost immediately after unspooling. It has made no detrimental impacts to my various systems, and so there isn't much reason for me to look elsewhere.