Pilot's headsets with active noise reduction have been around for quite a while now so the technology is fairly mature, particularly where the noise spectrum of aircraft is concerned. Most pilots I know either have them or want them. A friend of mine has owned a Bose ANR headset for a few years. It is well made, comfortable, and performs well. At $1000, it is also roughly twice as expensive as other well made, comfortable, well performing headsets.
Dave H