I have one room (13X22) which contains a 6.1 HT and two (2) channel set-ups.
On one short wall I have the HT front 3 speakers (2-CW, C-7 center) and an old style Water heater SVS PB sub woofer.
On the opposite short wall, I have the K-Horns. Between the K-horns is a CW Rear Center for the HT setup.
The second two channel rig, I have a set of Belles. The Belles are on a long, short 1/2 wall that separates the main room and the kitchen.
I have a swivel rocker that is positioned just right so all I have to do is "spin around" to bounce back between 2 channel K-horns and the HT setup.
There is a couch on the opposite wall facing the Belle set-up.
None of the set-ups are ideal but works for me.