I have a lot of experience with medium format, but like a lot of things, decades ago, and in an all but gone format.
The Fujifilm digitals you are looking at seem to have been well reviewed for many years, and their optics seem to be well regarded.
Back in the day, 2 1/4 sq was the go to for portrait, landscape, nature (flowers & bugs) with a macro at 1:1 for life size images. You could crop and blow up to 16 x 20 easily, but we did some at 30 x 30, 30 x 40 cropped. Hasselblad for 2.25 square, and also some Mamiya RB67 (6 x 7) with 220 film.
The difference between 35 and 120 was quite substantial. Shooting the same subject, equivalent 35 mm film focal length lens, the same film to get the the best quality 16 x 20 we had a 4 x 5 inter-negative made from the 35, then they would blow up the inter-negative, that made it acceptable, but many times 11 x 14 was the max whereas 16 x 20 was pretty easy with 2.25 sq, or 6x7.
I messed around with a 4x5” view camera once, with a really nice Schneider lens, it was so much work. It’s just wasn’t worth the time and effort. If you need the bellows for field of view, architecture photos, the TS-tilt shift lenses got you close to that.